Endocrine Abstracts

Transthyretin (TTR) is a protein mainly synthesized by the liver and choroid plexus (CP) of the brain. Besides its role as a carrier for thyroid hormones, TTR also sequesters the amyloid beta (Aβ) peptide impairing its deposition in nervous tissues, and its concentrations in the cerebrospinal fluid (CSF) appear to be inversely correlated with Alzheimer’s disease (AD) onset and progression. Abundant evidence suggests that the depletion of progesterone (PROG) at menopa...

Transthyretin (TTR) is well documented as a carrier for thyroid hormones. It also binds retinol binding protein preventing its filtration trough the kidneys and therefore is involved in delivering retinol to target cells. Moreover, TTR sequesters amyloid-beta impairing its deposition in nervous tissues and possibly contributing to its removal. Despite its importance in mammalian physiology, there are few studies regarding the regulation of TTR synthesis. In silico analy...